Our work suggests that our lead therapeutic (AD04™) regulates the immune system to provide patients with a unique positive effect on the course of Alzheimer’s Disease pathology. Our vision is to provide patients with a disease-modifying therapeutic for early Alzheimer’s Disease, thereby making the world a distinctly better place.

Our Values

We Put the Patient First

All decisions are made with the best interest of the patient. Period.

We Go Against the Grain

Root-cause explanations — with experimental evidence — drive our work and may overturn widely held assumptions. Knowledge building is in our DNA.

We Do the Right Thing

Integrity is key. We seek win-win relationships with stakeholders inside and outside the organization. We are only as good as our word.

We Have Grit

Entrepreneurs at heart, we thrive taking on significant challenges and breaking new ground. In the words of Marie Curie, “I was taught that the way of progress was neither swift nor easy.”

Why AD04™ as single ingredient has a different effect than when it is included in vaccines (for example AD02)?

Vaccines using Alhydrogel® (e.g. AD02) contain in addition an antigen, which plays a central role in guiding the immune response. Thus, AD04™ as single ingredient stimulates necessarily the immune system in a different way.

What is the mode of action of AD04™ as protective agent in AD?

AD04™ tested in preclinical studies improved cognition, mirroring the results of the clinical trial. Nevertheless, the mode of action of AD04™ on Alzheimer’s brain is not fully understood. Our hypothesis is that AD04™ regulates the immune system in a way that reduces AD pathology. To test this assumption, we are conducting additional preclinical studies in parallel to clinical development. We aim to demonstrate how AD04™ regulates cellular/molecular processes associated to neuroinflammation and neurodegeneration. For that purpose, we use state-of-the-art multi-omics, biochemistry, and immunohistology techniques. 

How are the preclinical studies of AD04™ informing the clinical development?

Concomitantly to defining the mode of action of AD04™, the preclinical studies aim to identify pharmacodynamic biomarkers easily accessible (e.g. in the blood) that will then be tested in the clinical trial. Such biomolecules, so-called surrogate markers of clinical outcome, are important in clinical trials to measure more accurately pathway and/or target engagement (enabling dose selection), and to obtain faster data of the therapeutic impact of the tested compound (enabling decisions on the next phase of development).

We have observed that AD04™, an immuno-modulator, is effective in the clinic having an effect in the brain, particularly on the hippocampus, a part associated to memory; with this understanding, we have built a pipeline of discovery-stage compounds (see Table).

Our strategy focuses on deep learning from AD04™-triggered biological pathways to..

…harness specific circuits of the immune system to inhibit AD

…create therapeutics tackling specific biomolecules having specific function(s) along these pathways, e.g novel immuno-modulator of a neuro-inflammatory axis in the hippocampus

Thus, AD10 to AD13 are discovery-stage drugs that will be selected for their impact on relevant pharmacodynamic biomarkers identified in the AD04™ preclinical program (see § “How are the preclinical studies of AD04™ informing the clinical development?”).  

Lipids and lipid circuits play a crucial role in the pathogenesis of AD, reflecting the fact that the brain is an organ with high lipid content. We investigate compounds potentially able to restore lipid homeostasis in the brain.

Using an appropriate panel of pharmacodynamics biomarkers that will be identified in the AD04™ preclinical program, we plan to setup an investigational blood-based diagnostic assay for AD.

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